Substituted hydroxy-heterocyclyl-alkoxyphosphinyloxy-...

C - Chemistry – Metallurgy – 07 – F

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C07F 9/59 (2006.01) A61K 31/66 (2006.01) C07F 9/655 (2006.01) C07F 9/6553 (2006.01)

Patent

CA 1276024

ABSTRACT Compounds of formula I Image wherein R represents hydrogen, C14-18 - alkyl or CH2OR2 or CH2CH2OR2, wherein R2 represents C14-18alkyl each R1 represents independently C1-3 alkyl m is 1 or 2 n is an integer from 2 to 8 and R4 and R5 together with the adjacent carbon atom represent Image (a) (b) (c) (d) Image (e) (f) or (g) wherein R3 represents alkyl, alkenyl, alkynyl, alkoxy, alkenoxy or alkynoxy each containing 12 to 24 carbon atoms whereby when R4 and R5 together with the adjacent carbon represent (i) ring e) R is H and (ii) other than ring e) R is other than H which exhibit pharmaceutical in particular anti-tumor activity.

517110

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