C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/06 (2006.01) A61K 31/496 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2650401
Certain novel substituted imidazole 4-carboxamides are ligands of the human cholecystokinin receptor and, in particular, are selective ligands of the human cholecystokinin-1 receptor (CCK-1R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of CCK-1R, such as obesity, and diabetes.
Selon cette invention, certains nouveaux 4-carboxamides d'imidazoles substitués sont des ligands du récepteur humain de la cholécystokinine et sont en particulier des ligands sélectifs du récepteur humain de la cholécystokinine (CCK-1R). Ils sont par conséquent utilisés pour le traitement, la maîtrise ou la prévention de maladies et de troubles réagissant à la modulation du récepteur CCK-1R, tels que l'obésité et le diabète.
Duffy Joseph L.
Edmondson Scott
Hansen Alexa
Zhu Cheng
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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