Substituted imidazole derivatives and their preparation and use

Details Substituted imidazole derivatives and their preparation and use Substituted imidazole derivatives and their preparation and use

C - Chemistry, Metallurgy

07

D

260/305, 260/314

C07D 405/10 (2006.01) C07C 45/63 (2006.01) C07C 45/69 (2006.01) C07C 45/74 (2006.01) C07C 49/217 (2006.01) C07D 233/54 (2006.01) C07D 405/06 (2006.01)

Patent

CA 1184559

ABSTRACT OF THE DISCLOSURE Novel substituted i?idazole derivatives of the formula: Image (I) or Image (II) and their non-toxic pharmceuticallly acceptable acid addition salts and mixtures thereof are provided herein. In such compounds R1 is H, an alkyl of 1 to 4 carbon atoms, or -CH2OH; R2 is H or CH3; R3 is CH3, CH2CH3, -CH2CH2CH3, Image , -CH2CH2CH2CH3, -CH2CH=CH2, or Image ; and R4 is H or OH; or R3 and R4 together represent =CH2 =CH-CH3, =CH-CH2-CH3, Image or =CH-CH2CH2CH3; X is Image or Image ; R5, R6 and R7, which can be the same or different are H, -CH3, -CH2CH3, halogen OH or -OCH3, or R5 is hydrogen and R6 and R7 together form an -O-CH2-O-bridge between two adjacent carbon atoms in the phenyl group; -CHR8- is -CH2-, -CH(CH3)-, -CH(-CH2CH3)-, -CH(-CH2CH2CH3)-, Image , Abstract - page 2 -CH(-CH?CH?CH?CH3)- Image , Image , Image , or Image ;R9 is H, -CH3, -CH2CH3, -CH2CH2CH3, Image , -CH2CH2CH2CH3 or OH; R10 is H, -CH3, -CH2CH3, -CH?CH2CH3, Image or -CH2CH2CH2CH3; R? is H, -CH3, -CH2CH3, -CH2CH2CH3, Image or -CH2CH2CH2CH3; and ? is 0 to 4. In ?uch compo? it ? provided that: - when R4 is OH, R1 is H or CH3 and ?3 in Image then R5, R6 and R7 are not all simultaneously hydrogen; - when R1, R2, and R4 all are hydrogen and R3 is Image , then R5, R6, R7 are not all simultaneously hydrogen; - R8 and R9 are not simultaneously hydrogen; and - R11 and R10 are not simultaneously hydrogen.

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