Substituted imidazole derivatives and their preparation and use

Details Substituted imidazole derivatives and their preparation and use Substituted imidazole derivatives and their preparation and use

C - Chemistry, Metallurgy

07

D

167/237, 260/314

C07D 233/56 (2006.01) A61K 31/415 (2006.01) C07D 233/54 (2006.01) C07D 233/64 (2006.01)

Patent

CA 2004799

ABSTRACT SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE Compounds of the formula: Image (I) wherein X is -CH2- or Image R1 is H, C1-5-alkyl or benzyl, which can be substituted or unsubstituted R2 is H, C1-4-alkyl, OH or C1-3-alkoxy R3 is H, CH3, CH2CH3, OCH3 or Hal R4 is H, CH3, CH2CH3, OCH3 or Hal and Hal is halogen and non-toxic acid addition salts and mixtures thereof are highly selective antagonists at postsynaptic .alpha.2-adrenocepeors, and are especlally useful in the treatment of diabetes.

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