C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/10 (2006.01) A61K 31/4178 (2006.01) A61K 31/427 (2006.01) A61K 31/433 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2637024
The present invention provides imidazole derivatives of Formula (I-IV), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I-IV), and their use in treating human or animal disorders. The compounds of the invention inhibit protein tyrosine phosphatase 1B and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases mediated by PTPase activity. Such diseases include Type I diabetes and Type II diabetes.
La présente invention concerne des dérivés d'imidazole de formule (I-IV), des procédés de préparation, des compositions pharmaceutiques incluant les composés de formule (I-IV), et leur utilisation dans le traitement des troubles humains ou animaux. Les composés de l'invention inhibent la protéine tyrosine phosphatase 1B et peuvent ainsi être utiles pour la gestion, le traitement, le contrôle, ou le traitement complémentaire des pathologies médiées par l'activité de la PTPase. De telles pathologies incluent le diabète de type I et le diabète de type II.
Andrews Robert C.
Mjalli Adnan M.m.
Polisetti Dharma R.
Quada, James C.
Subramanian Govindan
Smart & Biggar
Transtech Pharma Inc.
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