Substituted imidazoles as dual histamine h1 and h3 agonists...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 401/12 (2006.01) A61K 31/445 (2006.01) A61P 25/00 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2422210

The present invention discloses novel substituted imidazole compounds of Formula I: (see formula I) which have H3 receptor antagonist activity or dual histamine-H, and H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such imidazoles of Formula I as well as methods of using them to treat allergy, congestion, inflammatory and CNS-related diseases and others.

L'invention concerne des nouveaux composés substitués d'imidazole présentant une activité antagoniste du récepteur H3 ou une double activité antagoniste des récepteurs H1 et H3 de l'histamine. L'invention concerne également des procédés de préparation de tels composés. Dans un autre mode de réalisation, l'invention concerne des compositions pharmaceutiques renfermant de tels imidazoles, ainsi que des procédés d'utilisation de ceux-ci pour le traitement d'allergies, de congestion, de maladies inflammatoires et de maladies relatives au système nerveux central et analogues.

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