C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/54 (2006.01) A61K 31/415 (2006.01) A61P 25/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2421823
The present invention discloses novel substituted imidazole compounds which have either or dual histamine-H1 and H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such imidazoles as well as methods of using them to treat allergy, inflammatory and CNS-related diseases and others.
La présente invention concerne de nouveaux composés imidazole substituée qui possèdent une activité d'antagoniste pour le récepteur d'histamine H¿1? et/ou H¿3?, ainsi que des procédés de préparation de ces composés. Dans une autre forme de réalisation, cette invention concerne des compositions pharmaceutiques comprenant de telles imidazoles ainsi que des procédés d'utilisation de ces dernières pour traiter l'allergie, les maladies inflammatoires et les maladies liées au système nerveux central et autres.
Aslanian Robert G.
Mutahi Mwangi Wa
Piwinski John J.
Rosenblum Stuart B.
Shih Neng-Yang
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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