Substituted imidazoles as dual histamine h1 and h3 agonists...

Details Substituted imidazoles as dual histamine h1 and h3 agonists... Substituted imidazoles as dual histamine h1 and h3 agonists...

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 207/00 (2006.01) C07D 211/00 (2006.01) C07D 213/00 (2006.01) C07D 213/38 (2006.01) C07D 233/00 (2006.01) C07D 233/54 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2422729

The present invention discloses novel substituted imidazole compounds which have H3 receptor antagonist or dual histamine-H1 and H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such imidazoles as well as methods of using them to treat allergy, nasal congestion, inflammatory and CNS-related diseases and others.

L'invention concerne de nouveaux composés imidazole substitués qui possèdent une activité antagoniste du récepteur H¿3? ou une double activité antagoniste des récepteurs H¿1? et H¿3? de l'histamine ainsi que des procédés de préparation de ces composés. Dans un autre mode de réalisation, l'invention concerne des compositions pharmaceutiques comprenant ces imidazoles, ainsi que des procédés d'utilisation de ces compositions pour traiter des allergies, des congestions nasales, des maladies inflammatoires et des maladies liées au système nerveux central, notamment.

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