Substituted imidazoles as tafia inhibitors

Details Substituted imidazoles as tafia inhibitors Substituted imidazoles as tafia inhibitors

C - Chemistry, Metallurgy

07

D

C07D 233/64 (2006.01) A61K 31/00 (2006.01) A61K 31/415 (2006.01) A61K 31/4172 (2006.01) A61P 7/02 (2006.01) C07D 233/54 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2419633

The present invention provides compounds of formula (I). These compounds are a class of TAFIa inhibitors, which may be used in treating or preventing atherosclerosis, adhesions, dermal scarring, cancer, fibrotic conditions, inflammatory diseases and those conditions which benefit from maintaining or enhancing bradykinin levels in the body.

La présente invention concerne des composés de formule (I), qui sont une classe d'inhibiteurs TAFIa (Activate Thrombin activatable Fibrinolysis Inhibitor) particulièrement utilisés dans le traitement d'états pathologiques tels que l'athérosclérose, les adhérences, la cicatrisation dermique, le cancer, les états fibreux, les maladies fibreuses et tous les états qui peuvent bénéficier du maintien ou de l'augmentation des taux de bradykinine dans le corps.

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