C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07F 7/08 (2006.01)
Patent
CA 2297176
This invention relates to a series of substituted imidazoles of Formula (I), pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention inhibit the production of a number of inflammatory cytokines, and are useful in the treatment of diseases associated with overproduction of inflammatory cytokines.
L'invention a pour objet une série d'imidazoles substitués ayant la formule (I), des compositions pharmaceutiques comprenant ces imidazoles et des intermédiaires utilisés dans leur fabrication. Les composés faisant l'objet de cette invention inhibent la production de plusieurs cytokines inflammatoires et peuvent s'utiliser pour traiter des maladies liés à une surproduction de cytokines inflammatoires.
Beers Scott A.
Malloy Elizabeth
Wachter Michael P.
Wu Wei
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ortho-Mcneil Pharmaceutical Inc.
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