C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/56 (2006.01) A23L 3/3526 (2006.01) A23L 3/3544 (2006.01) A61K 8/49 (2006.01) A61K 31/415 (2006.01) A61K 31/4164 (2006.01) A61Q 11/00 (2006.01) A61Q 19/08 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2253788
The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein ageing). Accordingly, compositions are disclosed which comprise substituted imidazolium compounds capable of inhibiting the formation of, as well as reversing already formed, advanced glycosylation end products of target proteins. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein ageing can be treated.
La présente invention a trait à des compositions et à des procédéd permettant d'inhiber et d'inverser une réticulation non enzymatique (vieillissement de protéine). Ainsi, l'invention concerne des compositions contenant des composés d'imidazolium substitués pouvant inhiber la formation de produits terminaux de glycosylation évoluée de protéines cibles ou inverser le processus de cette formation lorsque ces produits sont déjà formés. Le procédé consiste à mettre en contact la protéine cible et la composition. Des applications tant industrielles que thérapeutiques de l'invention sont envisagées, étant donné que l'altération des aliments et le vieillissement de la protéine animale peuvent être inhibés.
Hwang San-Bao
Mallon Veronica M.
Wagle Dilip R.
Alteon Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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