Substituted imidazolyl-alkyl-piperazine and-diazepine...

Details Substituted imidazolyl-alkyl-piperazine and-diazepine... Substituted imidazolyl-alkyl-piperazine and-diazepine...

C - Chemistry, Metallurgy

07

D

167/208, 260/266

C07D 403/06 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 233/54 (2006.01)

Patent

CA 1320199

26080-FF ABSTRACT OF THE DISCLOSURE Substituted imidazolyl-alkyl-piperazine and diazepine derivatives of Formula A: Image FORMULA A wherein: R1 is aryl; R2 is aryl, lower alkyl, or hydrogen; R3 is lower alkyl, hydroxy, or hydrogen; R4 is aryl; R5 is aryl; m is two or three; n is zero, one or two, provided that when R3 is hydroxy, n is one or two; and q is zero, one, two, or three; and the pharmaceutically acceptable salts thereof, are useful for treating mammals having a variety of disease states, such as stroke, epilepsy or epileptic psychotic symptoms, hypertension, angina, migraine, arrhythmia, thrombosis, embolism, acute cardiac failure, irritable bowel syndrome, neurodegenerative diseases such as Alzheimer's or Huntington's chorea, diuresis, ischemia such as focal and global ischemia or cerebrovascular ischenmia induced by cocaine abuse, and also for treatment of spinal injuries. 705BY 26080-FF

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