C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4188 (2006.01) A61K 31/437 (2006.01)
Patent
CA 2710335
The present invention relates to substituted imidazopyridine derivatives as melanocortin-4 receptor (MC-4R) mod-ulators, in particular as melanocortin 4 receptor antagonists. The antagonists are useful for the treatment of disorders and diseases such as cachexia induced by e.g. cancer, chronic kidney disease (CKD) or chronic heart failure (CHF), muscle wasting, anorexia in-duced by e.g. chemotherapy or radiotherapy, anorexia nervosa, amyotrophic lateral sclerosis (ALS), pain, neuropathic pain, anxiety and depression.
La présente invention concerne des dérivés d'imidazopyridine substitués en tant que modulateurs des récepteurs de la mélanocortine 4 (MC-4R), notamment en tant qu'antagonistes des récepteurs de la mélanocortine 4. Les antagonistes sont utiles pour le traitement de troubles et de maladies tels que la cachexie induite, par exemple, par le cancer, l'insuffisance rénale chronique (CKD) ou l'insuffisance cardiaque chronique (CHF) l'atrophie musculaire, l'anorexie induite, par exemple, par la chimiothérapie ou la radiothérapie, l'anorexie mentale, la sclérose latérale amyotrophique (SLA), la douleur, la douleur neuropathique, l'anxiété et la dépression.
Feurer Achim
Nordhoff Sonja
Siendt Herve
Soeberdt Michael
Terinek Miroslav
Osler Hoskin & Harcourt Llp
Santhera Pharmaceuticals (schweiz) Ag
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