Substituted imidazopyridine derivatives as melanocortin-4...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 21/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2682329

The present invention relates to substituted imidazopyridine derivatives as melanocortin-4 receptor (MC-4R) modulators, in particular as melanocortin-4 receptor antagonists. The antagonists are useful for the treatment of disorders and diseases such as cancer cachexia, muscle wasting, anorexia, amytrophic lateral sclerosis (ALS), anxiety and depression.

La présente invention porte sur des dérivés d'imidazopyridine substitués tels que les modulateurs du récepteur de la mélanocortine-4 (MC-4R), en particulier comme antagonistes du récepteur de la mélanocortine-4. Les antagonistes sont utiles pour le traitement de troubles et maladies tels que la cachexie du cancer, la fonte musculaire, l'anorexie, la sclérose latérale amyotrophique (ALS), l'anxiété et la dépression.

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