Substituted imidazoquinolines and imidazonaphthyridines

Details Substituted imidazoquinolines and imidazonaphthyridines Substituted imidazoquinolines and imidazonaphthyridines

A - Human Necessities

61

K

A61K 31/4745 (2006.01)

Patent

CA 2597446

Imidazoquinolines and imidazonaphthyridines with a substituent containing a functional group, e.g., an amide, sulfonamide, urea, or heterocyclyl group, at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

L'invention concerne des imidazoquinolines et des imidazonaphthyridines comprenant un substituant qui contient un groupe fonctionnel, par exemple, un groupe amide, sulfonamide, urée ou hétérocyclyle, à la position 6, 7, 8 ou 9. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés, des intermédiaires, des procédés de production et des procédés d'utilisation de ces composés comme immunomodulateurs, afin d'activer la biosynthèse des cytokines chez les animaux et de traiter des maladies, notamment, des maladies virales et néoplasiques.

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