C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/4375 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07D 471/14 (2006.01)
Patent
CA 2634017
Certain 1H-imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydro-1H-imidazo[4,5- c]quinolines, 1H-imi-dazo[4,5-c][1,5]naphthyridines, 6,7,8,9-tetrahydro-1H-imidazo[4,5- c][1,5]naphthyridines, and 1H-imidazo[4,5-c]pyridines substituted at the 1- and 2-positions, pharmaceutical compositions containing these compounds, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
L'invention concerne certaines 1H-imidazo[4,5-c]quinoléines, 6,7,8,9-tétrahydro-1H-imidazo[4,5-c]quinoléines, 1H-imidazo[4,5-c][1,5]naphtyridines, 6,7,8,9-tétrahydro-1H-imidazo[4,5-c][1,5]naphtyridines et 1H-imidazo[4,5-c]pyridines substituées en positions 1 et 2, des compositions pharmaceutiques contenant ces composés, des procédés de préparation des composés et des procédés d'utilisation de ces composés comme immunomodulateurs, pour induire la biosynthèse de cytokines chez des animaux et dans le traitement de maladies, y compris de maladies virales et néoplasiques.
Dressel Luke T.
Haraldson Chad A.
Heppner Philip D.
Krepski Larry R.
Kshirsagar Tushar A.
Coley Pharmaceutical Group Inc.
Smart & Biggar
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