Substituted imidazothiazoles as antidepressant agents

Details Substituted imidazothiazoles as antidepressant agents Substituted imidazothiazoles as antidepressant agents

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/425 (2006.01)

Patent

CA 2374915

Compounds of Formula (I) including pharmaceutically acceptable salts thereof, in which A is S or O; R1 is H, halo, a C1-3 alkyl group or a C1-3 alkylthio group; R2 is H or fluoro; and R3 is methyl, ethyl or isopropyl are useful in the treatment of depression, anxiety, psychoses (for example schizophrenia), tardive dyskinesia, obesity, drug addiction, drug abuse, cognitive disorders, Alzheimer's disease, cerebral ischaemia, obsessive-compulsive behaviour, panic attacks, social phobias, eating disorders such as bulimia, anorexia, snacking and binge eating, non-insulin dependent diabetes mellitus, hyperglycaemia, hyperlipidaemia, stress and in the treatment and/or prophylaxis of seizures, neurological disorders such as epilepsy and/or conditions in which there is neurological damage such as stroke, brain trauma, cerebral ischaemia, head injuries and haemorrhage.

L'invention concerne des composés représentés par la formule (I) dans laquelle A est S ou O; R¿1? est H, halo, un groupe alkyle C¿1-3? ou un groupe alkylthio C¿1-3?; R¿2? est H ou fluoro; et R¿3? est méthyle, éthyle ou isopropyle. L'invention concerne également des sels pharmaceutiquement acceptables de ces composés qui s'avèrent utiles pour le traitement de la dépression, de l'anxiété, des psychoses (par exemple la schizophrénie), de la dyskinésie tardive, de l'obésité, de la toxicomanie, de la surconsommation de médicaments, des troubles cognitifs, de la maladie d'Alzheimer, de l'ischémie cérébrale, des névroses obsessionnelles, des crises de panique, des phobies sociales, des troubles de l'alimentation du type boulimie, anorexie, frénésie alimentaire et manie des en-cas, du diabète non insulino-dépendant, de l'hyperglycémie, de l'hyperlipidémie, et du stress et pour le traitement et/ou la prophylaxie des troubles épileptiques, des troubles neurologiques tels que l'épilepsie et/ou les troubles dans lesquels on constate une altération neurologique du type crises d'apoplexie, lésions cérébrales, traumatismes crâniens et hémorragies cérébrales.

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