C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 279/22 (2006.01) A61K 31/155 (2006.01) A61K 31/265 (2006.01) A61K 31/33 (2006.01) C07C 309/27 (2006.01) C07C 309/59 (2006.01) C07C 311/47 (2006.01) C07C 317/50 (2006.01) C07C 327/54 (2006.01) C07D 207/337 (2006.01) C07D 213/58 (2006.01) C07D 295/155 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01)
Patent
CA 2211982
Indanylidineacetylguanidines I (see formula I) and their pharmaceutically acceptable salts wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and X have the meanings given in the claims, are effective inhibitors of the cellular sodium/proton antiport (Na +/H + exchanger), which, in numerous diseases (essential hypertension, atherosclerosis, diabetes and the like) is also increased in those cells which are readily accessible for measurements, such as, for example, in erythrocytes, platelets or leukocytes. They are also advantageous for the preparation of a medicament for the treatment or prophylaxis of disorders of lipid metabolism.
Ghate Anil Vasantrao
Gupte Ravindra Dattatraya
Jain Arun Kumar
Lal Bansi
Ramakrishna Nirogi Venkata Satya
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Aktiengesellschaft
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