Substituted indazole amides

Details Substituted indazole amides Substituted indazole amides

C - Chemistry, Metallurgy

07

D

C07D 231/56 (2006.01) A61K 31/416 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2754685

The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R4, R6, X, Y and Z are as defined herein. The compounds of Formula (I) have been found to act as glucokinase activators. Consequently, the compounds of Formula (I) and the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucokinase.

La présente invention porte sur un composé de Formule (I) ou sur un sel pharmaceutiquement acceptable de celui-ci, formule dans laquelle R1, R4, R6, X, Y et Z sont tels que définis présentement. Les composés de Formule (I) ont été trouvés agir comme activateurs de glucokinase. Par conséquent, les composés de Formule (I) et leurs compositions pharmaceutiques sont utiles pour le traitement de maladies, de troubles ou d'affections à médiation par la glucokinase.

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