Substituted indazole derivatives and their use as inhibitors...

Details Substituted indazole derivatives and their use as inhibitors... Substituted indazole derivatives and their use as inhibitors...

C - Chemistry, Metallurgy

07

D

C07D 231/56 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 409/08 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01)

Patent

CA 2252982

The invention relates to compounds of formula (I), and to pharmaceutically acceptable salts thereof, wherein R and R1 are as defined herein. R2 is selected from the group consisting of (Ia), (Ib), (Ic) and (Id). The invention further relates to intermediates for the preparation of the compounds of formula (I), and to pharmaceutical compositions containing, and methods of using, the compounds of formula (I), or pharmaceutically acceptable salts thereof, for the inhibition of phosphodiesterase (PDE) type IV or the production of tumor necrosis factor (TNF) in a mammal.

L'invention concerne des composés de la formule (I) ainsi que des sels de ceux-ci, acceptables sur le plan pharmacologique. Dans cette formule R et R¿1? possèdent les notations données dans la description et R¿2? est choisi dans le groupe constitué par (Ia), (Ib), (Ic) et (Id). L'invention concerne en outre l'utilisation d'intermédiaires dans la préparation des composés de la formule (I), des compositions pharmaceutiques contenant ces composés de la formule (I) ou des sels de ceux-ci, acceptables sur le plan pharmacologique, ainsi que des procédés d'emploi de ces composés pour inhiber la phosphodiestérase (PDE) de type IV ou pour produire le facteur de nécrose tumorale (TNF) chez un mammifère.

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