C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/14 (2006.01) A61K 31/416 (2006.01) A61P 25/00 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2529353
The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): Formula (I), R2 is selected from the group consisting of -C1-8alkyl-Z, -C2-8alkenyl-Z and -C2-8alkynyl-Z; wherein the -C1- 8alkyl-Z, -C2-8alkenyl-Z and -C2-8alkynyl-Z and Z is a 5 to 6 member aromatic monocyclic heteroaryl ring having from 2 to 4 heteroatoms. These compounds are useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
L'invention concerne des composés de pyrroline à substitution indazolyle de formule (I). R?2¿ peut être alkyle-Z C¿1-8?, alcényle-Z C¿2-8?, et alkynyle-Z C¿2-8?, lesquels forment avec Z une chaîne hétéroaryle monocyclique aromatique qui comporte entre 2 et 4 hétéroatomes. Les composés considérés sont utiles comme inhibiteurs de kinase et de kinase double. L'invention concerne également des procédés relatifs à l'élaboration des composés en question, et des procédés de traitement ou d'amélioration de troubles dont la médiation est assurée par la kinase ou la kinase double.?¿
Maryanoff Bruce E.
Ye Hong
Zhang Han-Cheng
Janssen Pharmaceutica N.v.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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