C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/94 (2006.01) A61K 31/403 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2665468
Synthesis of novel substituted indeno[1,2-b]indole derivatives of the type of 5,6,7,8-tetrahydroindeno[1,2-b]indole-9,10-diones and 5H-indeno[1,2-b]indole-6,9,10-triones, which show pronounced inhibition of the human protein kinase CK2, and the use thereof as active ingredients in medicaments and/or drug products in particular for the treatment of neoplastic diseases.
Synthèse de nouveaux dérivés d'indéno[1,2 b-]indole substitués du type des 5,6,7,8-tétrahydroindéno[1,2-b]indol-9,10-diones et des 5H-indéno-[1,2-b]indol-6,9,10-triones, qui présentent un effet marqué d'inhibition de la protéine kinase CK2 humaine, et leur utilisation comme principes actifs de médicaments et/ou agents thérapeutiques, notamment pour le traitement d'affections néoplasiques.
Gotz Claudia
Hemmerling Hans-Jorg
Jose Joachim
Heinrich-Heine Universitaet Duesseldorf
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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