Substituted indole compounds having nos inhibitory activity

Details Substituted indole compounds having nos inhibitory activity Substituted indole compounds having nos inhibitory activity

C - Chemistry, Metallurgy

07

D

C07D 409/12 (2006.01) A61K 31/395 (2006.01) A61P 25/04 (2006.01) A61P 25/06 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) C07D 401/04 (2006.01) C07D 405/12 (2006.01) C07D 409/14 (2006.01) C07D 453/02 (2006.01) C07D 471/04 (2006.01) C07D 471/08 (2006.01)

Patent

CA 2605073

The present invention features inhibitors of nitric oxide synthase (NOS)5 particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing conditions such as, for example, stroke, reperfusion injury, neurodegeneration, head trauma, CABG, migraine headache with and without aura, migraine with allodynia, central post-stroke pain (CPSP), neuropathic pain, morphine/opioid induced tolerance and hyperalgesia.

La présente invention concerne des inhibiteurs de synthase d'oxyde nitrique (NOS), notamment ceux qui inhibent sélectivement la synthase d'oxyde nitrique (nNOS) préférablement à d'autres isoformes de NOS. Les inhibiteurs de NOS de l'invention, seuls ou en combinaison avec d'autres agents pharmaceutiquement actifs, peuvent être utilisés pour traiter ou prévenir des affections telles que, par exemple, l'accident cérébrovasculaire, la lésion de reperfusion, la neurodégénérescence, le traumatisme crânien, le pontage aortocoronarien, les maux de tête migraineux avec et sans aura, la migraine avec allodynie, la douleur centrale post-AVC, la douleur neuropathique, la tolérance induite par morphine/opioïde et l'hyperalgésie.

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