C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) C07C 317/46 (2006.01) C07C 323/62 (2006.01) C07D 209/22 (2006.01) C07D 215/14 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 491/052 (2006.01)
Patent
CA 2090042
Abstract There are disclosed compounds of the formula: A(CH2)nO-B, wherein A is C4-C8 alkyl, phenoxyethyl, phenoxyphenyl or a group having formula (a) or (b), wherein X is -N- or (c); Z is (d),(e),(f),(g),-S- or -O-;R1 is hydrogen, lower alkyl, phenyl or phenyl substituted with trifluoromethyl; R2 is hydrogen or lower alkyl; or R1 and R2 taken together form a benzen ring; R? is hydrogen or lower alkyl; n is 1-2; B is (h),(i),(j) or (k); wherein R4 is -CO2R2, (l), (m), (n), (o) or (p); m is 0-3; R5 is (q); or phenyl or phenyl substituted by halo, lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl; R6 is A(CH2)nO- or halo; with the proviso that when R6 is ha- lo, R5 is (r); R7 is lower alkyl; Y is CH2- or -O-; R8 is lower alkyl or -(CH2)mCO2R3; R9 is (5) or -CH2R10; R10 is lower alkyl, phenyl, phenyl substituted with carboxy, halo, loweralkylthio or loweralkylsulfinyl, pyridyl, fura- nyl or quinolinyl; R11 is lower alkyl or phenyl; and the pharmacologically acceptable salts thereof, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated naso-bronchial obstructive air-pas- sageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotec- tive agents.
Demerson Christopher A.
Failli Amedeo A.
Kreft Anthony F. III
Musser John H.
Shah Uresh S.
American Home Products Corporation
Demerson Christopher A.
Failli Amedeo A.
Kreft Anthony F. III
Musser John H.
LandOfFree
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