Substituted indoles as alpha-1 agonists

Details Substituted indoles as alpha-1 agonists Substituted indoles as alpha-1 agonists

C - Chemistry, Metallurgy

07

D

C07D 209/00 (2006.01) C07D 403/06 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2473803

This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha- 1A/L receptor agonists, and which are represented by the general formula I wherein X is -S(O)n- or -C(O)-, A is (CI-6)-alkyl, aryl, heteroaryl, hydroxy(C 1-6)-alkyl, or -(CH2)p-NRaRb, and the other substituents are as defined in the specification; or individual isomers, racemic or non- racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, their preparation and their use as therapeutic agents.

L'invention concerne des composés qui sont des agonistes du récepteur alpha-1, de préférence des agonistes du récepteur alpha-1A/L, et qui sont représentés par la formule générale (I), dans laquelle X représente -S(O)¿n?- ou -C(O)-, A représente (C<SB>I-6</SB>)-alkyle, un aryle, un hétéroaryle, hydroxy(C ¿1-6?)-alkyle, ou -(CH¿2?)¿p?-NR?a¿R?b¿, et les autres substituants sont tels que définis dans la revendication ou des isomères individuels, des mélanges racémiques ou non racémiques d'isomères ou des sels acceptables pharmaceutiquement ou des solvates correspondants. Cette invention a également trait à des compositions pharmaceutiques renfermant de tels composés, à leur préparation et à leur utilisation comme agents thérapeutiques.

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