C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) A61K 31/404 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61K 31/55 (2006.01) A61P 9/10 (2006.01) C07D 209/40 (2006.01) C07D 401/04 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 403/10 (2006.01) C07D 405/12 (2006.01) C07D 409/04 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2537097
The present invention relates to a series of substituted indole derivatives of the formula I as described herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5~-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
L'invention concerne une série de dérivés d'indoles substitués de formule (I) où R, R1, r2, R3, R4, X and Y sont tels que définis dans ce document. L'invention concerne en outre des procédés pour la production desdits composés. Lesdits composés sont inhibiteurs de polymérase de poly(ADP-ribose) (PARP) et ils sont ainsi utiles comme agents pharmaceutiques, en particulier pour le traitement et/ou la prévention d'une diversité de maladies, incluant les maladies associées au système nerveux central et aux troubles cardio-vasculaires.
Eastwood Paul R.
Jiang John Z.
Koehl Jack R.
Mehdi Shujaath
Moorcroft Neil
Aventis Pharmaceuticals Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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