C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/34 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/55 (2006.01) C07D 209/30 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2328291
The invention relates to substituted indolinones of general formula (I) in which R1 to R5 and X are defined as in Claim No. 1, to the isomers thereof, and to their salts, especially to the physiologically compatible salts thereof, which exhibit valuable pharmacological characteristics, especially an inhibiting effect on different kinases and cyclin/CDK complexes, and on the proliferation of different tumor cells. The invention also relates to medicaments containing these compounds, to their use, and to a method for the production thereof.
La présente invention concerne des indolinones substituées correspondant à la formule générale (I), dans laquelle les groupes R¿1? à R¿5? et X correspondent à la définition donnée dans la revendication 1, leurs isomères et leurs sels, en particulier leurs sels physiologiquement compatibles, qui présentent des caractéristiques pharmacologiques précieuses, en particulier un effet inhibiteur sur différentes kinases et sur différents complexes cycline/CDK, ainsi que sur la prolifération de différentes cellules tumorales, des médicaments contenant ces composés, leur utilisation et leur procédé de production.
Grell Wolfgang
Heckel Armin
Redemann Norbert
Van Meel Jacobus C. A.
Walter Rainer
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Boehringer Ingelheim Pharma Kg
Fetherstonhaugh & Co.
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