Substituted indolinones, their manufacture and their use as...

Details Substituted indolinones, their manufacture and their use as... Substituted indolinones, their manufacture and their use as...

C - Chemistry, Metallurgy

07

D

C07D 209/34 (2006.01) A61K 31/404 (2006.01) A61P 43/00 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2381821

The invention relates to substituted indolinones of the general formula (I), in which R1 to R6 and X are defined as per claim 1, to their isomers and salts, in particular, their physiologically compatible salts which exhibit valuable pharmacological properties, in particular an inhibiting effect on various receptor tyrosine kinases, cyclin/CDK complexes and also on the proliferation of endothelial cells and different tumour cells. The invention also relates to medicaments containing these compounds, to their use and to a method for their production.

L'invention concerne des indolinones substituées de formule générale (I), dans laquelle R¿1? à R¿6? et X sont définis dans la revendication 1, leurs isomères et leurs sels, notamment leurs sels physiologiquement tolérables, qui présentent des propriétés pharmacologiques intéressantes, notamment un effet inhibiteur sur différentes tyrosine kinases de récepteur, sur des complexes cycline/kinase dépendante des cyclines, ainsi que sur la prolifération de cellules endothéliales et de différentes cellules tumorales. L'invention concerne également des médicaments contenant ces composés, leur utilisation et leur procédé de production.

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