Substituted indolizine-like compounds and methods of use

Details Substituted indolizine-like compounds and methods of use Substituted indolizine-like compounds and methods of use

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61P 35/00 (2006.01) C07D 239/30 (2006.01) C07D 401/04 (2006.01) C07D 471/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2466072

Selected novel substituted indolizine-like compounds are effective for treatment of diseases, such as TNF-.alpha., IL-1.beta., IL-6 and/or IL-8 mediated diseases, and other maladies, such as cancer, pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for treatment of diseases and other maladies or conditions involving inflammation, cancer, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

L'invention concerne des nouveaux composés de type indolizine substitués sélectionnés efficaces dans le traitement de pathologies, par exemple des pathologies à médiation assurée par le TNF-.alpha., l'IL-1.beta., l'IL-6 et/ou l'IL-8, et d'autres pathologies comme le cancer, la douleur ou le diabète. L'invention concerne également des nouveaux composés, analogues, des promédicaments et des sels pharmaceutiquement acceptables de ceux-ci, des compositions pharmaceutiques et des méthodes de traitement de pathologies et d'autres maladies ou états comprenant l'inflammation, le cancer, la douleur, le diabète et analogues. L'invention concerne en outre des procédés de production desdits composés ainsi que des produits intermédiaires utiles dans lesdits procédés.

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