Substituted indoloquinoxalines

Details Substituted indoloquinoxalines Substituted indoloquinoxalines

C - Chemistry, Metallurgy

07

D

167/224, 260/246

C07D 487/04 (2006.01) A61K 31/495 (2006.01)

Patent

CA 1303613

ABSTRACT Substituted indoloquinoxalines of the general formula I Image I wherein R1 represents one or several, preferably 1 to 4, similar or different substituents in the positions 1-4 and/or 7-10, selected from halogen, preferably Br, lower alkyl/alkoxy group having not more than 4 carbon atoms, trifluoromethyl group, trichloromethyl group; X is a group -(CH2)n-R2 wherein R2 represents a nitrogen containing basic residue such as NH2, NHR4 or NR5R6 wherein R4, R5 and R6 independently are lower alkyl or cycloalkyl and n is an integer of from 1 to 4 and R3 represents hydrogen, lower alkyl/cycloalkyl group having not more than 4 carbon atoms, and the physiologically acceptable addition products of the compounds with acids and halogen adducts, preferably adducts with iodine, iodine monochloride or iodine monobromide. Also methods for preparing said compounds by reacting a compound of the formula II Image II with a reactive compound containing the residue -CHR3X, or by rearranging a compound the formula III Image III by heating are described. The novel indoloquinoxalines have antiviral effect and have effect against cancer.

527660

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