A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/42 (2006.01) C07D 277/04 (2006.01)
Patent
CA 2522759
The invention relates to novel heterocyclic compounds having the structure illustrated by Formula (1) wherein the Ar1 radicals are substituted isochroman radicals, the Ar2 radicals are aryl or heteroaryl radicals; and HAr is a 2,4- thiazolidinedione, 2-thioxo-thiazolidine-4-one, 2,4-imidazolidinedione or 2- thioxo-imidazolidine-4-one radical. The compounds of Formula (1) can have biological activity for advantageously regulating carbohydrate metabolism, including serum glucose level, and lipid metabolism, and can be useful for the treatment of hyperlipidernia and/or hypercholesterolemia, and Type 11 diabetes. The compounds of Formula (1) can also have utility in the treatment of diseases of uncontrolled proliferation, including cancer.
L'invention concerne de nouveaux composés hétérocycliques dont la structure correspond à la formule (I), dans laquelle les radicaux Ar¿1? sont des radicaux isochromanes substitués, les radicaux Ar¿2? sont des radicaux aryle ou hétéroaryle, et HAr est un radical 2,4-thiazolidinedione,2-thioxothiazolidine-4-one,2,4-imidazolidinedione ou 2-thioxoimidazolidine-4-one. Les composés correspondant à la formule (I) peuvent présenter une activité biologique régulant, de façon avantageuse, le métabolisme des glucides, y compris le taux de glucose sérique, et le métabolisme des lipides, et ils peuvent être utilisés dans le traitement de l'hyperlipidémie et/ou de l'hypercholestérolémie, ainsi que du diabète de type II. Les composés correspondant à la formule (I) peuvent également être utilisés dans le traitement de maladies impliquant une prolifération non contrôlée, y compris le cancer.
Al-Shamma Hussien A.
Boudjelal Mohamed
Chen Qing
Giachino Andrea Fanjul
Guo Jianhua
Incyte San Diego Incorporated
Mbm Intellectual Property Law Llp
Ortho-Mcneil Pharmaceutical Inc.
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