Substituted isoindoles as bace inhibitors and their use

Details Substituted isoindoles as bace inhibitors and their use Substituted isoindoles as bace inhibitors and their use

C - Chemistry, Metallurgy

07

D

C07D 209/44 (2006.01) A61K 31/4035 (2006.01) A61K 31/4433 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) A61P 25/28 (2006.01) C07D 401/10 (2006.01) C07D 403/10 (2006.01) C07D 407/14 (2006.01)

Patent

CA 2656625

This invention relates to novel compounds having the structural formula I and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.

La présente invention concerne des nouveaux composés de formule structurale (I) et leur sel pharmaceutiquement acceptable, ainsi que leurs compositions et leurs procédés d'utilisation. Ces nouveaux composés permettent d'assurer le traitement ou la prophylaxie de troubles cognitifs, de la maladie d'Alzheimer, de la neurodégénérescence et de la démence.

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