Substituted isoquinoline derivatives and methods of use

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 401/12 (2006.01) A61K 31/4375 (2006.01) A61K 31/4704 (2006.01) A61K 31/4709 (2006.01) A61K 31/498 (2006.01) A61K 31/4985 (2006.01) C07D 217/24 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2534571

Compounds of formula (I) are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

L'invention à trait à des composés de formule (I) assurant la prophylaxie et le traitement de maladies telles que celles médiées par angiogenèse. L'invention porte sur ces nouveaux composés, leurs analogues, leurs prodrogues et leurs sels pharmacocompatibles, sur des méthodes de prophylaxie et de traitement de maladies et autres états dont le cancer et analogues, et sur les procédés d'obtention desdits composés et des intermédiaires requis par lesdits procédés.

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