Substituted isoquinolines as ultra short acting...

C - Chemistry – Metallurgy – 07 – D

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C07D 217/20 (2006.01) A61K 31/47 (2006.01) A61K 31/4725 (2006.01) A61P 21/02 (2006.01)

Patent

CA 2284802

Ultrashort acting neuromuscular blocking agents of Formula (I) which are useful as skeletal muscle relaxants during emergency intubation procedures, routine surgery and post-operative settings are disclosed, wherein: X is halogen; h is from 1 to 2; Y is hydrogen or methoxy; Z1 and Z2 are methyl; W1 and W2 are carbon; and A is a pharmaceutically acceptable anion.

Agents bloquants neuromusculaires exerçant une action ultracourte, représentés par la formule (I) et utiles en tant que relaxants des muscles du squelettes lorsqu'on pratique une intubation d'urgence, une intervention chirurgicale de routine et des mises au point postopératoires, dans laquelle: X représente halogène; h est 1 à 2; Y représente hydrogène ou méthoxy; Z<1> et Z<2> représentent méthyle; W<1> et W<2> représentent carbone; A est un anion acceptable sur le plan pharmaceutique.

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