C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/435 (2006.01) A61K 31/4439 (2006.01) A61K 31/495 (2006.01) A61K 31/5375 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2585053
The invention is directed to compounds of Formula (I): wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula (I), are also provided.
L'invention concerne des composés de formule (I), dans laquelle A, X, R2 et W sont tels que définis dans la description, ainsi que des solvates, des hydrates, des tautomères et des sels pharmaceutiquement acceptables desdits composés, qui inhibent les protéines tyrosine kinases, notamment la kinase c-fms. L'invention concerne également des méthodes de traitement de maladies auto-immunes ; et de maladies présentant une composante inflammatoire ; de traitement de métastases du cancer de l'ovaire, du cancer de l'utérus, du cancer du sein, du cancer du côlon, du cancer de l'estomac, de la leucémie à tricholymphocytes et du carcinome du poumon non à petites cellules ; et de traitement de la douleur, y compris de la douleur du squelette causée par des métastases tumorales ou arthrose, ou de la douleur viscérale, inflammatoire et neurogénique ; ainsi que de l'ostéoporose, de la maladie de Paget et d'autres maladies dans lesquelles une résorption osseuse induit une morbidité, notamment l'arthrite, l'insuffisance prothétique, l'ostéosarcome, le myélome et la métastase tumorale sur l'os, à l'aide des composés de formule (I).
Ballentine Shelley K.
Chen Jinsheng
Desjarlais Renee
Flores Christopher
Illig Carl R.
Janssen Pharmaceutica N.v.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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