C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 257/18 (2006.01) A61K 31/155 (2006.01) A61K 31/16 (2006.01) A61K 31/215 (2006.01) A61K 31/335 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) C07C 45/63 (2006.01) C07C 205/57 (2006.01) C07C 255/60 (2006.01) C07C 259/18 (2006.01) C07C 323/60 (2006.01) C07C 327/34 (2006.01) C07D 207/327 (2006.01) C07D 209/08 (2006.01) C07D 209/48 (2006.01) C07D 213/54 (2006.01) C07D 213/55 (2006.01) C07D 213/56 (2006.01) C07D 213/57 (2006.01) C07D 213/58 (2006.01) C07D 213/70 (2006.01) C07D 213/82 (2006.01) C07D 213/
Patent
CA 2241904
The compounds according to the invention are substituted N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides of formula (I) herein which exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More especially, they are Factor Xa inhibitors. The present invention is directed to compounds of formula (I), compositions containing compounds of formula (I), methods for their preparation and their use, which are for treating a patient suffering from, or subject to, conditions which can be ameliorated by the administration of an inhibitor of Factor Xa.
Composés constitués par des N-[(aminoiminométhyle ou aminométhyle)phényle]propylamides à substitution de la formule (I) exerçant une activité utile sur le plan pharmacologique et de ce fait incorporés dans des compositions pharmaceutiques pour le traitement de patients souffrants de certains troubles pathologiques. Ces composés sont plus spécialement des inhibiteurs du facteur Xa. L'invention porte sur des composés de la formule (I), des compositions contenant des composés de la formule (I), des méthodes de préparation et d'utilisation de ces composés pour le traitement d'un patient souffrant d'états pouvant être améliorés par l'administration d'un inhibiteur du facteur Xa.
Guertin Kevin R.
Klein Scott I.
Spada Alfred P.
Aventis Pharmaceuticals Inc.
Goudreau Gage Dubuc
Rhone-Poulenc Rorer Pharmaceuticals Inc.
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