Substituted n-aniline-4-chloro-3-sulphamoyl benzamides

Details Substituted n-aniline-4-chloro-3-sulphamoyl benzamides Substituted n-aniline-4-chloro-3-sulphamoyl benzamides

A - Human Necessities

61

K

260/542

A61K 31/18 (2006.01) A61K 31/165 (2006.01)

Patent

CA 1187899

ABSTRACT OF THE DISCLOSURE: The invention is related to substituted N-aniline- 4-chloro-3-sulphamoyl benzamides of general formula I Image (I) wherein R represents a hydrogen atom or methyl and R1 is methyl, ethyl, isopropyl, 2-hydroxyethyl or phenyl, and to a process for producing thereof consisting in acylation of substituted hydrazines of general formula II (II) Image with 4-chloro-3-sulphamoylbenzoyl chloride. Compounds of general formula I have diuretic and saliuretic activity and significant antihypertension effect.

410121

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