C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/08 (2006.01) A61K 31/167 (2006.01) A61P 25/28 (2006.01) C07C 235/56 (2006.01) C07C 237/40 (2006.01) C07D 235/26 (2006.01)
Patent
CA 2566090
Substituted diaryl compounds of the Formulae (I, II, III), where the variables are as defined in the claims, and their pharmaceutically acceptable derivatives, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including A.szlig. amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment are provided.
Des composés de diaryle substitués des formules (I, II, III), où les variables sont telles que défini dans les affirmations, et où leurs dérivés pharmaceutiquement acceptables, leur synthèse, les compositions pharmaceutiques les contenant et leur utilisation dans le traitement des maladies amyloïdes, notamment l'amylose A.szlig., comme cela est observé dans la maladie d'Alzheimer, l'amylose IAPP, comme cela est observé dans le diabète de type 2, et les synucléinopathies, comme cela est observé dans la maladie de Parkinson et la fabrication de médicaments pour ce traitement sont fournis.
Castillo Gerardo M.
Lake Thomas P.
Nguyen Beth P.
Snow Alan D.
Weigele Manfred
Osler Hoskin & Harcourt Llp
Proteotech Inc.
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