C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/47 (2006.01) A61K 31/4745 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01)
Patent
CA 2211326
Substituted N-arylmethyl and heterocyclylmethyl-1H-pyrazolo[3,4-b]quinolin-4- amines, pharmaceutical compositions containing them and methods for a) effecting c-GMP-phosphodiesterase inhibition, b) treating heart failure and/or hypertension, c) reversing or reducing nitrate-induced tolerance and d) treating angina pectoris, congestive heart disease and myocardial infarction utilizing them.
Cette invention concerne des n-arylméthyl et hétérocyclylméthyl-1H- pyrazolo[3,4-b] quinolin-4-amines substituées, des compositions pharmaceutiques contenant ces composés ainsi que des procédés utilisant ces composés pour (a) inhiber la c-GMP-phosphodiestérase, (b) traiter l'insuffisance cardiaque et/ou l'hypertension, (c) inverser ou réduire la tolérance vis-à-vis des nitrates et (d) traiter l'angine de poitrine, l'insuffisance cardiaque congestive et l'infarctus du myocarde.
Dority John A. Jr.
Kumar Virendra
Fetherstonhaugh & Co.
Sanofi Pharmaceuticals Inc.
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