C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 255/58 (2006.01) A61K 31/16 (2006.01) A61K 31/27 (2006.01) A61K 31/275 (2006.01) A61K 31/415 (2006.01) C07C 225/20 (2006.01) C07C 233/41 (2006.01) C07C 271/24 (2006.01) C07C 271/36 (2006.01) C07C 311/07 (2006.01) C07C 311/20 (2006.01) C07D 233/61 (2006.01)
Patent
CA 2261072
The compounds of formula (I) wherein R1, R2, R3 and A are as defined herein are useful, via potassium channel modulation, in the treatment of disorders associated with smooth muscle contraction. Such disorders include, but are not limited to, urinary incontinence, hypertension, asthma, premature labor, irritable bowel syndrome, congestive heart failure, angina and cerebral vascular disease.
L'invention porte sur des composés de formule (I) dans laquelle R¿1?, R¿2?, R¿3? et A sont tels que définis dans la description, et qui s'avèrent utiles, par modulation des canaux potassium, pour le traitement de troubles associés à la contraction des muscles lisses. Lesdits troubles comprennent non limitativement: l'incontinence urinaire, l'hypertension, l'asthme, l'accouchement prématuré, le côlon irritable, l'insuffisance cardiaque globale, l'angor et les affections vasculaires cérébrales.
Antane Madelene Miyoko
Butera John Anthony
Gilbert Adam Matthew
Graceffa Russell Francis
Gundersen Eric Gould
American Home Products Corporation
Ridout & Maybee Llp
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