Substituted n-cycloalkylmethyl-1h-pyrazolo[3,4-b¦quinolin-4...

Details Substituted n-cycloalkylmethyl-1h-pyrazolo[3,4-b¦quinolin-4... Substituted n-cycloalkylmethyl-1h-pyrazolo[3,4-b¦quinolin-4...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/47 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2211317

Substituted N-cycloalkylmethyl-1H-pyrazolo[3,4-b]quinolin-4-ammines, pharmaceutical compositions containing them and methods for a) effecting c-GMP-phosphodiesterase inhibition, b) treating heart failure and/or hypertension, c) reversing or reducing nitrate-induced tolerance, and d) treating angina pectoris, congestive heart disease and myocardial infarction utilizing them.

N-cycloalkylméthyl-1H-pyrazolo[3,4-b]quinolin-4-ammines substituées, compositions pharmaceutiques contenant ces composés et méthodes a) pour provoquer une inhibition de la c-GMP-phosphodiestérase, b) pour traiter l'insuffisance cardiaque et/ou l'hypertension, c) pour inverser ou atténuer la tolérance induite par les nitrates et d) traiter l'angine de poitrine, l'insuffisance cardiaque globale et l'infarctus du myocarde à l'aide de ces composés.

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