C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/179, 260/277
C07C 215/64 (2006.01) A61K 31/40 (2006.01) C07C 45/00 (2006.01) C07C 45/46 (2006.01) C07C 45/63 (2006.01) C07C 45/71 (2006.01) C07C 49/577 (2006.01) C07C 49/697 (2006.01) C07C 49/747 (2006.01) C07C 49/753 (2006.01) C07C 62/32 (2006.01) C07C 62/34 (2006.01) C07C 211/30 (2006.01) C07C 215/50 (2006.01) C07C 217/74 (2006.01) C07C 229/50 (2006.01) C07C 233/18 (2006.01) C07C 255/47 (2006.01) C07C 259/08 (2006.01) C07C 323/22 (2006.01) C07D 207/06 (2006.01) C07D 207/08 (2006.01) C07D 207/335 (2006.01) C07D 213/38
Patent
CA 1337425
The present invention includes compounds represented by the formula: Image wherein n is 0 or 1; R1, R2, R3, and R4 are independently selected from hydrogen, hydroxyl, amino, alkylamino, alkylsulfonylamino, loweralkyl, loweralkoxy, halo, and thioalkoxy; R1 and R2 or R2 and R3 taken together can form a methylenedioxy or ethylenedioxy bridge; R10 is independently selected from hydrogen, loweralkyl, phenyl, and substituted phenyl; R5 is loweralkyl; R9 is hydrogen or loweralkyl; R6 and R8 are hydrogen; and R7 is Image wherein m is 0, 1 or 2; X is CH2, O, S or N-CH3; or R7 is Image wherein s is 0, 1, or 2; Z is C or N; R11 and R12 are independently selected from hydrogen, halo, hydroxy, methoxy, thiomethoxy, amino and loweralkyl, or R11 and R12 taken together can form a methylenedioxy or ethylenedioxy bridge; or R7 is Image wherein t is 0 or 1; or R5 and R9 taken together form a pyrrolidine ring and then R6 and R8 are hydrogen and R7 is as described above; or R5 and Rg taken together form a pyrrolidine ring and then R6 is hydrogen and R7 and R8 taken together may form a phenyl, substituted phenyl, thienyl or furyl ring; or R5 and R8 taken together form a pyrrolidine ring and then Rg and R6 are hydrogen and R7 is phenyl, substituted phenyl, thienyl, or furyl; or R7 and R9 are hydrogen and R6 is benzyl, substituted benzyl, thienylmethyl, or furylmethyl; or a pharmaceutically acceptable salt thereof.
588246
Basha Fatima Zehra
de Bernardis John Francis
Zelle Robert Edward
Abbott Laboratories
Goudreau Gage Dubuc
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