C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/42 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/675 (2006.01) A61K 31/70 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 413/12 (2006.01) C07D 417/00 (2006.01) C07D 417/12 (2006.01) C07F 9/572 (2006.01) C07H 15/26 (2006.01)
Patent
CA 2223625
This invention relates to certain indole-2-carboxamides of formula (I) and the pharmaceutically acceptable salts and prodrugs thereof, wherein R6 is carboxy, (C1-C8)alkoxycarbonyl, C(O)NR8R9 or C(O)R12, useful as inhibitors of glycogen phosphorylase, methods of treating glycogen phosphorylase dependent diseases or conditions with such compounds and pharmaceutical compositions comprising such compounds.
L'invention concerne certains indole-2-carboxamides de formule (I) ainsi que leurs sels et promédicaments pharmaceutiquement acceptables. Dans la formule (I), R¿6? représente carboxy, alcoxycarbonyle (C¿1?-C¿8?), benzyloxycarbonyle, C(O)NR¿8?R¿9? ou C(O)R¿12?. Ces composés servent d'inhibiteurs de la glycogène phosphorylase. L'invention concerne également des procédés pour traiter les maladies ou états dépendant de la glycogène phosphorylase au moyen de ces composés et des compositions pharmaceutiques contenant ces composés.
Hoover Dennis J.
Hulin Bernard
Martin William H.
Treadway Judith L.
Pfizer Inc.
Smart & Biggar
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