C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/675 (2006.01) A61K 31/70 (2006.01) C07D 205/04 (2006.01) C07D 207/12 (2006.01) C07D 209/42 (2006.01) C07D 211/46 (2006.01) C07D 235/24 (2006.01) C07D 263/06 (2006.01) C07D 277/04 (2006.01) C07D 277/14 (2006.01) C07D 277/34 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/00 (2006.01) C07D 405/12 (2006.01) C07D 409/00 (2006.01) C07D 409/12 (2006.01) C07D 413/00 (2006.01) C07D 417/12 (2006.01) C07D 417
Patent
CA 2224062
Compounds of Formula (1) wherein R6 is carboxy, (C1-C8)alkoxycarbonyl, benzyloxycarbonyl, C(O)NR8R9 or C(O)R12 as glucogen phosphorylase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat diabetes, hyperglycemia, hypercholesterolemia, hypertension, hyperinsulinemia, hyperlipidemia, atherosclerosis and myocardial ischemia in mammals.
L'invention concerne des composés de formule (1) où R¿6? représente carboxy, alcoxycarbonyle (C¿1?-C¿8?), benzyloxycarbonyle, C(O)NR¿8?R¿9? ou C(O)R¿12?, servant d'inhibiteurs de la glycogène phosphorylase, ainsi que des compositions pharmaceutiques contenant ces inhibiteurs. L'invention concerne également l'utilisation de ces inhibiteurs pour le traitement du diabète, de l'hyperglycémie, de l'hypercholestérolémie, de l'hypertension, de l'hyperinsulinémie, de l'hyperlipidémie, de l'athérosclérose et de l'ischème myocardiaque chez les mammifères.
Hoover Dennis J.
Hulin Bernard
Martin William H.
Phillips Douglas
Treadway Judith L.
Limited Pfizer
Smart & Biggar
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