Substituted n-phenyl-2-cyano-3-hydroxy-enamides

Details Substituted n-phenyl-2-cyano-3-hydroxy-enamides Substituted n-phenyl-2-cyano-3-hydroxy-enamides

C - Chemistry, Metallurgy

07

C

C07C 255/44 (2006.01) A61K 31/275 (2006.01) A61K 31/36 (2006.01) C07C 255/19 (2006.01) C07C 255/23 (2006.01) C07C 323/41 (2006.01) C07D 317/60 (2006.01)

Patent

CA 2086908

Compounds of formula (I) (see formula I) [wherein R1 represents a group of formula (see formula II, III,IV, and V) (in which R13, R14 and R15, which may be the same or different, each represents a hydrogen atom, a halogen atom or an alkyl group containing 1 to 3 carbon atoms and n represents 1, 2 or 3); R2 represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms; R3, R4, R5, R6 and R7, which may be the same or different, each represents a hydrogen atom, a halogen atom, a group NO2, a cyano group, a linear or branched alkyl group containing 1 to 6 carbon atoms, a linear or branched alkylcarbonyl group containing 2 to 6 carbon atoms, a cycloalkyl group containing 3 to 6 carbon atoms, a linear or branched alkoxy group containing 1 to 6 carbon atoms, a linear or branched alkylthio group containing 1 to 6 carbon atoms, a group selected from -(CH2)m-CF3 , -O- (CH2)m-CF3, -S- (CH2)m-CF3, 2 -CF2-Hal, -O-CF2-Hal, Image (wherein m represents 0, 1, 2 or 3; n represents 1, 2 or 3; Hal, Hal1, Hal2 and Hal3, which may be the same or different, each represents a halogen atom) or a group of formula Image (wherein R8, R9, R10, R11 and R12, which may be the same or different, each represents any of those groups defined above for R3, R4, R5, R6 and R7); or R4 and R5 together represent a group -O-CH2-O-,whilst R3, R6 and R7 are as defined above]; and base addition salts thereof, possess anti-inflammatory and immunomodulatory activity. Processes for preparing them, intermediate compounds used in their preparation and composi- tions containing them are also described.

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