Substituted n-phenyl-bipyrrolidine carboxamides and...

C - Chemistry – Metallurgy – 07 – D

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C07D 207/06 (2006.01) A61K 31/4025 (2006.01) A61P 25/00 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2702467

The present invention discloses and claims a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I) as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this invention also discloses methods of preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefor.

La présente invention concerne et revendique une série de carboxamides de N-phényl-bipyrrolidine substitués de formule (I) telle que décrite dans le présent document. Plus particulièrement, les composés de cette invention sont des modulateurs des récepteurs H3 et sont, par conséquent, utiles en tant qu'agents pharmaceutiques, en particulier dans le traitement et/ou la prévention d'une variété de maladies modulées par les récepteurs H3, y compris les maladies associées au système nerveux central. De plus, cette invention concerne également des procédés de préparation de carboxamides de N-phényl-bipyrrolidine substitués et de leurs composés intermédiaires.

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