Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 207/09 (2006.01) A61K 31/4025 (2006.01) A61P 25/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2702834

The present invention discloses and claims a series of substituted N-phenyl-pyrrolidinylmethylpyrrolidine amides of formula (I) as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this invention also discloses methods of preparation of substituted pyrrolidinylmethylpyrrolidine amides and intermediates therefor.

La présente invention concerne une série d'amides de N-phényl-pyrrolidinylméthylpyrrolidine substitués de formule (I) tels que décrits ici. Plus particulièrement, les composés de la présente invention sont des modulateurs des récepteurs H3 et sont, par conséquent, utiles comme agents pharmaceutiques, en particulier dans le traitement et/ou la prévention d'une variété de maladies modulées par des récepteurs H3 comprenant des maladies associées avec le système nerveux central. De plus, cette invention décrit également des procédés de préparation d'amides de N-phényl-pyrrolidinylméthylpyrrolidine substitués et d'intermédiaires de ceux-ci.

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