C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/28 (2006.01) A61K 31/4015 (2006.01) A61K 31/402 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) C07D 401/06 (2006.01)
Patent
CA 2655675
The present invention relates to novel oxo-prolinamide derivatives of formula (I) which modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of disorders mediated by the P2X7 receptor, for example pain, inflammation and neurodegeneration.
Nouveaux dérivés oxo-prolinamide de formule (I) qui modulent la fonction de récepteur P2X7 et sont capables de jouer le rôle d'antagonistes vis-à-vis des effets de l'ATP au récepteur P2X7, et utilisation de ces composés ou compositions pharmaceutiques correspondantes dans le traitement de troubles dont la médiation est assurée par ce récepteur, par exemple la douleur, l'inflammation et la neurodégénérescence.
Chambers Laura J.
Gleave Robert
Senger Stefan
Walter Daryl Simon
Glaxo Group Limited
Gowling Lafleur Henderson Llp
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