C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61P 29/02 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2531506
Inhibitors of MIF having a naphthyridine backbone are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: (Ia), (Ib), (Ic), (Id) including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R, R1, R2, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
La présente invention concerne des inhibiteurs du facteur d'inhibition de la migration des macrophages qui présentent un squelette de naphtyridine. Ces inhibiteurs sont utilisés pour traiter une variété de troubles, notamment des pathologies associées à une activité de facteur d'inhibition de la migration des macrophages. Lesdits inhibiteurs présentent les structures suivantes: (Ia), (Ib), (Ic), (Id) qui comprennent des stéréoisomères, des promédicaments et des sels de ceux-ci, acceptables d'un point de vue pharmaceutique, dans lesquelles n, R, R¿1?, R¿2?, X, Y et Z sont tels que définis dans cette invention. La présente invention concerne également des compositions contenant un inhibiteur du facteur d'inhibition de la migration des macrophages combiné à un support acceptable d'un point de vue pharmaceutique, ainsi que des procédés pour les utiliser.
Davis Timothy James
Kumar Sunil K.c.
Sircar Jagadish
Ying Wenbin
Avanir Pharmaceuticals
Smart & Biggar
LandOfFree
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