Substituted naphthyridinone derivatives

Details Substituted naphthyridinone derivatives Substituted naphthyridinone derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4375 (2006.01)

Patent

CA 2544191

Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson~s disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.

L'invention concerne de nouveaux composés de formule structurale (1), qui sont des antagonistes et/ou des agonistes inversés du récepteur de cannabinoïde 1 (CB1) et s'utilisent dans le traitement, la prévention et la suppression de pathologies induites par le récepteur de CB1. Lesdits composés s'utilisent comme médicaments à action centrale dans le traitement de la psychose, des déficiences de la mémoire, des troubles cognitifs, de la migraine, de la neuropathie, des troubles neuro-inflammatoires, y compris la sclérose en plaques et le syndrome de Guillain-Barré et les séquelles inflammatoires de l'encéphalite virale, les accidents vasculaires cérébraux, ainsi que les traumatismes crâniens, les troubles anxieux, le stress, l'épilepsie, la maladie de Parkinson, les troubles du mouvement et la schizophrénie. Lesdits composés s'utilisent également dans le traitement de troubles de la toxicomanie, de l'obésité ou des troubles de l'alimentation, de même que dans le traitement de l'asthme, de la constipation, de la pseudo-obstruction intestinale chronique, et de la cirrhose du foie.

Affiliated with

Also associated with

Rating

Substituted naphthyridinone derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted naphthyridinone derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted naphthyridinone derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1993900